synthetic biology

The Synthetic Biology Open Language – SBOL

The re-use of previously validated designs is critical to the evolution of synthetic biology from a research discipline to an engineering practice. Here we describe the Synthetic Biology Open Language (SBOL), a proposed data standard for exchanging designs within the synthetic biology community. SBOL represents synthetic biology designs in a community-driven, formalized format for exchange […]

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

During the 2009 H1N1 influenza pandemic, vaccines for the virus became available in large quantities only after human infections peaked. To accelerate vaccine availability for future pandemics, we developed a synthetic approach that very rapidly generated vaccine viruses from sequence data. Beginning with hemagglutinin (HA) and neuraminidase (NA) gene sequences, we combined an enzymatic, cell-free […]

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Next-generation DNA sequencing

This article is an interesting review of how Next-Generation sequencing differs from traditional Sanger sequencing, along with the pros and cons of each approach.  Overall, the advantage of NextGen sequencing seems to be that it bypasses some of the traditional bottlenecks of Sanger sequencing, such E. Coli transformation and colony selection, and can be done […]

Writing DNA with GenoCAD

This paper is a little dated now but I still like to look at these screenshots. They are good memories of a time when GenoCAD was blazing a new trail in synthetic biology. Several years later, we are still living the vision. It just takes longer than expected to make it a reality.

What is Gene Synthesis?

This article explains what is gene synthesis, a combination of chemical and biological processes to produce synthetic DNA that does not exist in nature.  This technology transforming genetic engineering from a laborious art to an information-driven discipline. Although substantial advances have been made in the development of gene synthesis, the methods employed vary widely based on […]

Analyzing the Registry of Standard Biological Parts

The design and construction of novel biological systems by combining standard biological parts represents a dominant paradigm in synthetic biology. Creating and maintaining a database of these building blocks is a way to streamline the fabrication of complex constructs. The Registry of Standard Biological Parts (Registry) is the most advanced implementation of this idea.By analyzing […]