Noise in synthetic genetic oscillators

Title:

Sources of Variability in a Synthetic Gene Oscillator

Author(s):

Alan Veliz-Cuba Andrew J. Hirning Adam A. Atanas Faiza Hussain Flavia Vancia Krešimir Josić Matthew R. Bennett Gabor Balazsi

Publication:

Published in: PLOS Computational Biology
Volume: 11, Issue: 12, Pages: e1004674-
Published: 12/22/2015
DOI: 10.1371/journal.pcbi.1004674
Website: http://dx.plos.org/10.1371/journal.pcbi.1004674

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This paper focuses on characterizing the stochastic dynamics of previously described synthetic genetic oscillators. It is a very nice combination of experimental and computational work. The computational aspect includes both image analysis and parameter estimation. They breakdown the noise into different components including intrinsic noise, cell cycle noise, and parameter variability by looking at the expression of genes in cell lineages across several generations.