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Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

Title:

Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

Author(s):

Tatjana Trcek Daniel R. Larson Alberto Moldón Charles C. Query Robert H. Singer

Publication:

Published in: Cell
Volume: 147, Issue: 7, Pages: 1484-1497
Published: 12//2011
DOI: 10.1016/j.cell.2011.11.051
Website: http://linkinghub.elsevier.com/retrieve/pii/S0092867411014450

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Great paper describing the cell cycle dependence of the degradation of SWI5 and CLB2 mRNA. They use single molecule FISH on unsynchronized populations to quantify mRNA abundance, as well as nascent transcripts.