Journal Club

Decoupling assembly and submission standards

Decoupling assembly and submission standards

Rule-based design of synthetic transcription factors

Rule-based design of synthetic transcription factors

To design and build living systems, synthetic biologists have at their disposal an increasingly large library of naturally derived and synthetic parts. These parts must be combined together in particular orders, orientations, and spacings to achieve desired functionalities. These structural...

Adaptive Imaging Cytometry

Adaptive Imaging Cytometry

The use of microfluidics in live cell imaging allows the acquisition of dense time-series from individual cells that can be perturbed through computer-controlled changes of growth medium. Systems and synthetic biologists frequently perform gene expression studies that require changes in...

The Synthetic Biology Open Language – SBOL

The Synthetic Biology Open Language – SBOL

The re-use of previously validated designs is critical to the evolution of synthetic biology from a research discipline to an engineering practice. Here we describe the Synthetic Biology Open Language (SBOL), a proposed data standard for exchanging designs within the...

Article-level metrics and the evolution of scientific impact

Article-level metrics and the evolution of scientific impact

This is one of the first and best papers about the use of article-level metrics. It provides a detailed overview of the different options and their possible adoption challenges, Interestingly, the paper also discusses how to use them to help...

If You Can’t Measure It, You Can’t Manage It

If You Can’t Measure It, You Can’t Manage It

This article is part of the About My Lab Collection.

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

This is a very extensive review that provides many interesting perspectives on the difficult problem of reverse engineering of gene networks. In particular, it draws a lot of connections with disciplines outside of the life sciences.

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

During the 2009 H1N1 influenza pandemic, vaccines for the virus became available in large quantities only after human infections peaked. To accelerate vaccine availability for future pandemics, we developed a synthetic approach that very rapidly generated vaccine viruses from sequence...

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