Journal Club

Theoretical uncertainty of measurements using quantitative polymerase chain reaction

Theoretical uncertainty of measurements using quantitative polymerase chain reaction

Control of Stochasticity in Eukaryotic Gene Expression

Control of Stochasticity in Eukaryotic Gene Expression

This paper uses the dual reporter approach to measuring gene expression developed by Elowitz (see this journal club entry). The authors look at different promoters. In all cases, the intrinsic noise was a small fraction of the total noise. The...

Theoretical uncertainty of measurements using quantitative polymerase chain reaction

Theoretical uncertainty of measurements using quantitative polymerase chain reaction

Current quantitative polymerase chain reaction (PCR) protocols are only indicative of the quantity of a target sequence relative to a standard, because no means of estimating the amplification rate is yet available. The variability of PCR performed on isolated cells...

Markovian Modeling of Gene-Product Synthesis

Markovian Modeling of Gene-Product Synthesis

There was good intuition behind this paper. It took forever to get the first citations but it’s been well cited in 2012 and 2013. Sort of a long term investment.  

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