stochastic model

/Tag: stochastic model

Noisy foresight

Twenty years ago, I was just a boy with a crazy dream of building stochastic models of the noise affecting the expression of genes in living cells. Back in the 90s this idea sounded like an heresy. The dominant paradigm of the time was to consider that gene regulation was a qualitative and deterministic process [...]

Noisy foresight2019-02-06T19:38:07+00:00

Leave it to chance or not

Carolyn Beans wrote a blog post about our project to develop stochastic models of the regulatory network controlling cell division.  She was particularly interested in aspects of cell physiology that are affected by random events and how cells manage to remain healthy despite the vagaries of molecular interactions. Read her post on the NIGMS Biobeat [...]

Leave it to chance or not2019-02-06T19:38:11+00:00

Stochastic modeling of the cell cycle goes on…

A couple of weeks ago, we received the renewal of the NIH grant funding our collaboration with John Tyson to develop stochastic models of the regulatory network controlling the cell cycle in yeast. This is the third funding cycle of this project that started in 2006. This renewal did not as smoothly as we had [...]

Stochastic modeling of the cell cycle goes on…2019-02-06T19:38:31+00:00

Measurements modeling transcription noise makes the cover of Cell Cycle

The October issue of Cell Cycle includes an article reporting our efforts to measure and model the transcriptional noise affecting the the regulatory network controlling the cell cycle in the baker yeast (Saccharomyces cerevisiae). The journal cover page features an image derived from this work.   Cell Cycle. 2013 Sep 4;12(19). [Epub ahead of print] Measurement [...]

Measurements modeling transcription noise makes the cover of Cell Cycle2019-02-06T19:42:59+00:00