I published a blog post entitled “Cloning forever” in which I show how biologists struggle with the notion of design applied to recombinant DNA. I hypothesize that most molecular biologists are still very focused on deriving new plasmids from existing ones using standard cloning techniques. Using a specific example, I explain the potential benefits of making the effort to use a principled approach to the design expression systems prior to initiating the experimental work. Read the full post.